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Evusheld: COVID-19 Prevention

You can protect yourself before you are exposed to COVID-19 by getting vaccinated, choosing the right mask, knowing what increases your risk of being exposed, and taking action to prevent it.

If you are immunocompromised (have a weakened immune system), having COVID-19 can be especially dangerous. Vaccines are the best way to prevent a serious COVID-19 infection. In addition, a therapy called Evusheld may reduce your chances of getting COVID-19 if it is taken before you are exposed.

What Causes a Person to Be Immunocompromised?

People may be immunocompromised if they:

  • Have a disease or an infection such as HIV, cancer, or diabetes
  • Have been treated with certain drugs or with radiation
  • Have had a solid organ transplant, such as a kidney or heart transplant
  • Have inherited problems with their immune system, such as a primary immunodeficiency
  • Have taken certain types of medicines (such as corticosteroids) for a long time, leading to secondary or acquired immunodeficiency
  • Have other immunocompromising conditions

See the full list of who may qualify as immunocompromised.

Immunocompromised Conditions

Evusheld: A Prevention Therapy for COVID-19

WHAT is Evusheld?

Evusheld is a prevention therapy for people who have a weakened immune system. Evusheld contains two monoclonal antibodies (tixagevimab and cilgavimab) to help your body fight the virus that causes COVID-19.

WHO is eligible for Evusheld?

Evusheld is used in adults and children (12 years of age and older, weighing at least 88 pounds [40 kg]) for prevention of COVID-19 in persons:

  • Who are not currently infected with SARS-CoV-2, the virus that causes COVID-19, and who have not had recent known close contact with someone who is infected with SARS-CoV-2; AND
  • Who have moderate to severe immune compromise due to a medical condition or have received immunosuppressive medicines or treatments and may not mount an adequate immune response to COVID-19 vaccination; OR
  • For whom vaccination with any available COVID-19 vaccine, according to the approved or authorized schedule, is not recommended, due to a history of severe adverse reaction to a COVID-19 vaccine(s) or COVID-19 vaccine ingredient(s).

WHEN should immunocompromised patients receive Evusheld?

Evusheld should be given before you are exposed to or infected with COVID-19. Evusheld is intended to help prevent serious consequences of COVID-19, such as hospitalization or death. If you test positive for COVID-19 before or after you receive Evusheld, there are medications that can help prevent your symptoms from getting worse.

Learn More About COVID-19 Treatment Options

HOW do I get Evusheld?

If you do not have a history of allergic reaction to a COVID-19 vaccine or vaccine ingredients, talk to a health care provider about receiving the COVID-19 vaccine and booster before you receive Evusheld. Evusheld is given as an intramuscular injection every 6 months. A health care provider can help you find where Evusheld is available near you, using the Therapeutics Locator.

suggested question icon 

Suggested Questions for Your Doctor or Health Care Provider:

  • Am I eligible for Evusheld?
  • Can my child receive Evusheld?

Evusheld Personal Story and Informational Videos

Patient Story


My name is Lashon Berry. I'm 45 years old and I live in Mesquite, Texas.

I was diagnosed with pulmonary fibrosis in April of 2012. When the COVID pandemic first arrived on the scene, it was very frightening. As a lung transplant recipient, our lungs are already very sensitive to just the simple things in the air outside. So, now we have this COVID-19 on the scene that can cause even more damage to our lungs. So, at this point, I've made a decision that I'm totally in place in the house - quarantining myself so that I can keep my lungs safe.

So, that means no hospital visits. There's no grocery stores. That means increased masks, sanitizer.

When a transplant patient thinks of COVID, unfortunately, the first thing you think of is your demise. Because for the average person, that is not immunosuppressed, a cold is something simple to them. But it's the flu to us. The flu to the average person is pneumonia to us. Pneumonia to the average person is just like death to us.

My medical team did inform all transplant patients that the vaccines would not give us the same amount of protection as it would an average person that was not immunosuppressed.

But, you always want to increase your chances of protecting this organ. The gift of organ donation is absolutely one of the best gifts that one could give the opportunity to save someone else's life in such a selfless moment.

It's amazing to me. I'm grateful for my donor family. The feeling of protecting my gift after receiving the Evusheld shot was one of a little more freedom. I felt like now I could breathe a little bit, maybe go out to the grocery stores again, just begin to live more and not live in fear.

Evusheld has been an opportunity for me to continue to enjoy my gift and to live life, to go and do things such as attend my son's football games this fall, to attend my nephew's wedding, just to be able to enjoy the gift and enjoy life.

Millions of people can benefit from Evusheld, a drug for the prevention of severe COVID-19 symptoms in immunocompromised people. Watch Lashon Berry share her inspiring story about her double-lung transplant, and how she feels Evusheld helped her get back to living life.

Patient Story


Hi. I'm Dr. Brian Koffman. I'm a retired family doctor, and I live in Los Angeles County.

In 2005, I was diagnosed with chronic lymphocytic leukemia. Our cancer is a cancer of the immune system, and as such, we were extraordinarily vulnerable to the ravages of a COVID infection.

Evysheld provides similar levels of protection to those who cannot mount a response to the vaccines, which should be the frontline protection for the majority of people.

I think it's important to understand how Evusheld works. It's only used to prevent COVID, just like a vaccination.

This is the pre-exposure prophylaxis. Evusheld is giving me antibodies that my B-cells can't make. And it's two antibodies that attach to different parts of the spike protein - the coronavirus that causes COVID-19. And these have been proven to be very effective neutralizing antibodies.

Once I had Evusheld on board, it was a sense of, "Now I'm protected." I have the same kind of protection that someone who's been vaccinated and has had a robust response to the vaccine enjoyed. I did feel more comfortable going on a plane to see my daughter and grandkids who I had not seen in two years.

I did feel more comfortable meeting with colleagues to discuss some of the research and things we were doing with the Evusheld aboard. I felt like, "Hey, I can reengage in the world." It was incredibly liberating.

As a health care provider speaking to another health care provider, I say, "Don't leave the immunocompromised patients behind. Pre-Exposure prophylaxis with Evusheld is probably your absolute best option for protecting these patients from symptomatic COVID and death."

Dr. Brian Koffman, Evusheld recipient and Chief Medical Officer/Executive Vice President of the Chronic Lymphocytic Leukemia Society, shares his experience with receiving the drug.

Doctor Explanation


Hello. My name is Alfredo Meno Lora. I'm an infectious disease specialist and I work at Saint Anthony Hospital in Chicago and the University of Illinois at Chicago.

Monoclonal antibodies are very interesting therapeutics because we can create monoclonal antibodies, which are basically photocopies of antibodies against a specific target. And for COVID, our specific target, similar to vaccines, is the spike protein. So, what you get are antibodies ready-made that will attack the spike protein of the coronavirus.

What makes Evusheld different and interesting is that it's a long acting version of this medication and therefore people can receive the medication and it remains in their body for a prolonged period of time. And when they get exposed to COVID 19, they will have the defenses ready to protect them against the disease.

So, it is a prophylactic drug rather than a therapeutic drug. It is meant to prevent the disease rather than treat the disease.

Evusheld is recommended for folks who can't take the vaccine. And this could be for a variety of reasons, including adverse events or allergies or contraindications to the vaccines. The reality is that those indications are relatively rare and Evusheld is mostly used for individuals who have immuno-compromising conditions that despite the vaccine, are unable to have the full response from it.

Evusheld is available not just for adults but for children above the age of 12 who weigh over 40 kilograms.

There are no major contraindications for Evusheld. In general, what you should look out for is if you have any history of allergies to make sure that none of the components of Evusheld are something that you are allergic to.

Patients should wait about approximately two weeks after getting their COVID vaccine in order to get every shot. And this is true for boosters and for your initial doses of the vaccine as well. And the concept here is similar to actively having COVID 19 or being exposed to somebody with COVID-19 recently. You want to make sure that you use Evusheld when you're going to get the maximum benefit from it.

I think the importance of a tool like Evusheld cannot be understated. Vaccines are the most important choice, but in individuals where the vaccines can't go as far as the general population, Evusheld is an extremely important and the best tool in the toolbox to keep you healthy and safe in addition to vaccines, if you can take them.

Dr. Alfredo J. Mena Lora, Infectious Disease Specialist at St. Anthony Hospital in Chicago, explains how health care professionals can use Evusheld in their practice for people who are immunocompromised or cannot get the COVID-19 vaccine.

What is Evusheld?



Hello, I am Dr. Michael Anderson. I’m an intensive care physician and a senior advisor at the Department of Health and Human Services Office of the Assistant Secretary for Preparedness & Response, also known as ASPR. At ASPR I help guide the novel COVID-19 therapeutics as well as focus on a pediatric response agenda. I’d like to talk with you about a very unique therapeutics that is used to prevent infection and that’s called Evusheld.

What is Evusheld?

Evusheld is a long-acting antibody used for pre-exposure prophylaxis, also known as PrEP. The drug can provide protection against infection of people not expected to mount an adequate immune response.

Who is eligible for Evusheld?

Evusheld is for adults and children 12 and over who are immunocompromised due to a medical condition or immunosuppressive medications. Evusheld is also for rare individuals for whom vaccination is not recommended due to a medical, health reason. Evusheld of course is not a substitute for vaccination.

As a PrEP treatment, Evusheld is for people not currently infected with COVID-19 and who have not been recently exposed to COVID-19. Evusheld is not a treatment for active COVID-19 infections. For more information about patient eligibility and administration of Evusheld, please see the resources found in the description and other videos in this series.

How is Evusheld administered?

Evusheld is given as two intramuscular injections at one sitting, ideally into the gluteal muscle. Before going home, patients should monitored for one hour after injection for any signs of severe but very rare allergic reactions.

What are the limitations of use for Evusheld?

Evusheld is not for people who test positive for COVID-19. Vaccination and boosters are recommended for immunocompromised individuals and any close contacts or household members. Evusheld does require a prescription and patients should wait at least 2 weeks after getting the COVID-19 vaccine before receiving Evusheld. Evusheld should be administered with caution in patients who have a coagulopathy or patients at risk for cardiovascular disease.

Evusheld is one of several COVID-19 therapeutics. I urge you to watch the other videos in this outpatient series. Also visit us online at and please see the resources linked in the description to learn more. You can also connect with ASPR on social media platforms to stay up to date on our latest posts and information. And if you have any questions I urge you to email us at

Thank you for your time.

Evusheld protects those who are not expected to mount an adequate immune response following vaccination. This video featuring Michael Anderson, MD, MBA, Senior Advisor at ASPR, discusses the use of Evusheld, a long-acting monoclonal antibody combination for use in pre-exposure prophylaxis (PrEP) of COVID‑19.