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Ordering HHS-Provided JYNNEOS through HPOP

ASPR/CDC Mpox Vaccination Operational Planning Guide - HHS Mpox Vaccination Program

Product Ordering

Thresholds for JYNNEOS ended on April 30, 2024. On April 30, 2024, HHS closed ordering against thresholds by setting all thresholds to zero. If additional supply is still required in circumstances where commercial supply is not available or accessible, JYNNEOS is available by request using the established out-of-cycle (OOC) request process. Ordering of the HHS-procured JYNNEOS will fully close on August 1, 2024 at 12 PM ET. Please note that an OOC request needs to be placed at least 48 hours in advance of any orders to allow time for adjudication and processing. Any OOC request to support ordering before the August 1 close date must be made by July 30, 2024 at 12 pm ET. Availability through CDC’s routine vaccine programs is anticipated on or near August 1, 2024. 

  • Ordering smaller quantities will aid the jurisdictions, enabling targeting vials where they are needed most and minimizing wastage. This will help jurisdictions reduce the need to redistribute vials to correct for less-than-optimal placement throughout the jurisdiction.
  • Jurisdictions should feel free to plan and schedule vaccine distribution, clinics, second doses, and events as you continue to use supply per CDC recommendations.
  • Orders are fulfilled by the SNS to deliver these medical countermeasures. Please submit any questions concerning order status, shipment delivery updates, and temperature validation directly to SNS at sns.ops@hhs.gov. 
  • The minimum order quantity (MOQ) for USG-provided JYNNEOS is 20 vials. All orders must be placed in increments of 20.

The following are required for ordering JYNNEOS through HPOP:

  • Reporting administration data in the IIS system.
  • Inventory reporting in HPOP.
  • Product specifications (HHS distributed supply):
    • Labeled as a single-dose vial (0.5mL), 20 vials per box, box dimensions 5.5 x 1.5 x 4 inches. The actual fill volume of each vial is 6.4mL.
    • Minimum order quantity (MOQ) is 1 box, 20 vials.

To continue slowing the spread of mpox, jurisdictions should focus on ordering vaccines to be distributed in areas of highest transmission. If there is little ongoing transmission, vaccination efforts should focus on increasing vaccination coverage for those at risk of exposure to mpox with an emphasis on reducing disparities.

Supplemental Orders Above Thresholds (Out-of-Cycle Requests)

Jurisdictions must use the out of cycle (OOC) request process after April 30, 2024. All OOC requests must be places by July 30, 2024 at 12 PM ET to allow for processing before ordering fully closes on August 1, 2024 at 12 PM ET. Requests for vaccine should include sufficient demonstration of the commitment to use previously distributed and commercial supply as the primary options. Additional JYNNEOS vaccine should only be requested to improve vaccination rates within recommended populations while commercial availability and reimbursement systems ramp up and only to support access in circumstances in which commercial product is not available or accessible. 

Jurisdictions may initiate a request for additional vials through the established OOC request process in Tiberius. The request should include a description of why additional vaccine is needed, including why commercially available JYNNEOS vaccine is not accessible to the intended recipients. For more information regarding the OOC request process, please contact  contact SPD_AdminOMT@hhs.gov.

It is the responsibility of every provider who prepares and administers injections, or supervises those that prepare and administer injections, to make sure that patients receive the correct medication and are not exposed to life-threatening infections. Providers should adhere to  Standard Precautions and the principles of Safe Injection​ Practices, including the use of a sterile, single-use, disposable needles and syringes for each injection administered, and prevention of contamination of injection equipment and medication.

Product Transfer

Jurisdictions are encouraged to share/transfer excess product that has been stored according to its specifications. Product can be transferred within a jurisdiction or to other jurisdictions, if needed, in accordance to state and local regulations. We request that jurisdictions maintain inventory records regarding any products that are shared in the respective transferring and receiving entities’ documentation.​




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Operational Planning Guide