WHO Biorisk Management: Laboratory Biosecurity Guidance: In recent years, several countries have developed and implemented laboratory biosecurity legislation to regulate the possession, use, and access to biological materials. Despite the advances of some countries, in many other countries and for many laboratories, guidance or specific requirements for the appropriate handling and storage of valuable biological materials (VBM) do not yet exist. Valuable Biological Materials are “biological materials that require (according to their owners, users, custodians, caretakers or regulators) administrative oversight, control, accountability, and specific protective and monitoring measures in laboratories to protect their economic and historical (archival) value, and/or the population from their potential to cause harm” (WHO). Within a comprehensive biorisk management approach, this document aims to define and guide the reader in the field of laboratory biosecurity. It is addressed to laboratories wishing to handle and store VBM, and discusses the legal framework within countries holding and supporting such laboratories.