In developing Screening Framework Guidance for Providers and Users of Synthetic Nucleic Acids, the U.S. government consulted with representatives of synthetic nucleic acid providers and of manufacturers of benchtop nucleic acid synthesis equipment to understand their current practices. While there may be some differences in screening details between the U.S. government approach and that of individual providers or manufacturers, the overarching recommendations and intent are fairly consistent among industry and the U.S. government.
The screening approach strikes a balance between mitigating biosecurity risks and minimizing any negative impacts on the conduct of research or business operations. A goal in developing the guidance was to ensure it would be feasible for small and large providers, as well as international providers. The guidance provides an acceptable baseline.
These recommendations were developed to align with existing protocols and business practices, to be implemented without unnecessary cost, and to minimize any negative impacts on the conduct of research and business operations. Where practical to do so, entities should use existing business practices to verify the legitimacy of customers and colleagues to track the transfer of materials containing SOCs.
Finally, the guidance acknowledges that the ongoing development of best practices by providers in this area is commendable and encouraged.